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Research Overview

The Frontier laboratory is engaged in synthetic organic chemistry research, especially cyclization reactions that produce unusual, densely functionalized ring systems from simple precursors. Research directions being pursued in the lab include the study of novel pericyclic reactions, cationic rearrangements and diastereoselective cyclization cascades, and their application to complex molecule synthesis.

Research Interests

• Synthetic organic chemistry
• synthesis of bioactive natural products
• pericyclic reactions
• asymmetric catalysis
• cationic cascades

Recent Publications

Dylan E. Parsons, Alison J. Frontier Noncanonical Cation−π Cyclizations of Alkylidene β-Ketoesters: Synthesis of Spiro-fused and Bridged Bicyclic Ring Systems Organic Letters, 2019

Connor Holt, Georgios Alachouzos, Alison J. Frontier Leveraging the Halo-Nazarov Cyclization for the Chemodivergent Assembly of Functionalized Haloindenes and Indanones Journal of the American Chemical Society, 2019

Carlsen, P.N., Stoutenburg, E.G., Frontier, A.J. SYNTHESIS-SYNLETT Lecture: Toward the Asymmetric Synthesis of Tetrapetalone A: Preparation of an Enantioenriched Indane Intermediate and Strategy for Endgame Glycosylation Synthesis (Germany), 2018

Georgios Alachouzos, Alison J. Frontier Cationic Cascade for Building Complex Polycyclic Molecules from Simple Precursors: Diastereoselective Installation of Three Contiguous Stereogenic Centers in a One-Pot Process Journal of the American Chemical Society, 2018

Alachouzos, G., Frontier, A.J. Diastereoselective Construction of Densely Functionalized 1-Halocyclopentenes Using an Alkynyl Halo-Prins/Halo-Nazarov Cyclization Strategy Angewandte Chemie - International Edition, 2017

Huang, Y.-W., Frontier, A.J. Nazarov Cyclization/Internal Redox Cyclization Sequence for the Synthesis of N-Heterocyclic Bridged Ring Systems Organic Letters, 2016

Huang, Y.-W., Frontier, A.J. Enantioselective Nazarov cyclization catalyzed by a cinchona alkaloid derivative Tetrahedron Letters, 2015

Carlsen, P.N., Jiang, C., Herrick, I.R., Frontier, A.J. Studies toward the AB ring system of the tetrapetalone natural products Tetrahedron, 2015

Leboeuf, D., Ciesielski, J., Frontier, A.J. Erratum: Gold(I)-catalyzed iodination of arenes (Synlett (2014) 25 (399)) Synlett, 2015

Callahan, K.P., Minhajuddin, M., Corbett, C., Lagadinou, E.D., Rossi, R.M., et al. Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity Leukemia, 2014

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