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Research Overview

• Biological functions of RNA modifications
• Human disorders linked to RNA modifications
• Regulation of protein synthesis

Our laboratory investigates the emerging roles of RNA modification in biological processes ranging from protein synthesis to neurodevelopment. We use an integrated biochemical, molecular, and genetic approach that employs mammalian tissue culture cells, human brain organoids, and animal models such as Drosophila and mice. Through this approach, we have discovered novel targets and functions for RNA modification. The pathways and mechanisms identified through our studies have provided critical insight into multiple aspects of human health and disease, including anti-cancer chemotherapy, neurological disorders, and aging.

Research Interests

• Biological functions of RNA modifications
• Human disorders linked to RNA modifications
• Regulation of protein synthesis

Recent Publications

Caley Hogan, Scott Gratz, Jennifer L. Dumouchel, Rajan Thakur, Ambar Delgado Carrión, et al. EMBO reports, 2023

Kejia Zhang, Patrick Eldin, Jessica H. Ciesla, Laurence Briant, Jenna M. Lentini, et al. , 2023

Longan ER, Ramos J, Fu D microPublication biology, 2023

Jenna M. Lentini, Hessa S. Alsaif, Eissa Faqeih, Fowzan S. Alkuraya, Dragony Fu Nature Communications, 2020

Felix Hagelskamp, Kayla Borland, Jillian Ramos, Alan G Hendrick, Dragony Fu, et al. Nucleic Acids Research, 2020

Kejia Zhang, Jenna M. Lentini, Christopher T. Prevost, Mais O. Hashem, Fowzan S. Alkuraya, et al. Human Mutation, 2020

Human mutation, 2019

Jillian Ramos, Lu Han, Yan Li, Felix Hagelskamp, Stefanie M. Kellner, et al. Molecular and Cellular Biology, 2019

Jillian Ramos, Dragony Fu Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019

Chen Gu, Jillian Ramos, Ulrike Begley, Peter C. Dedon, Dragony Fu, et al. Science Advances, 2018

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